Major metabolite of clozapine. Potent serotonin 5-HT1c receptor antagonist.
Product Details
| Alternative Name: | Norclozapine |
| |
| Formula: | C17H17ClN4 |
| |
| MW: | 312.8 |
| |
| CAS: | 6104-71-8 |
| |
| Purity: | ≥99% (HPLC) |
| |
| Identity: | Determined by 1H-NMR. |
| |
| Appearance: | Yellow solid. |
| |
| Solubility: | Soluble in ethanol (25 mg/ml) or DMSO (>44 mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | Ambient |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One
6, e25395 (2011),
Abstract;
Full Text
Metabolism and bioactivation of clozapine by human liver in vitro: M. Pirmohamed, et al.; J. Pharmacol. Exp. Ther.
272, 984 (1995),
Abstract;
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors: B.L. Roth, et al.; J. Pharmacol. Exp. Ther.
268, 1403 (1994),
Abstract;
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol.
245, 179 (1993),
Abstract;
On-line fully automated determination of clozapine and desmethylclozapine in human serum by solid-phase extraction on exchangeable cartridges and liquid chromatography using a methanol buffer mobile phase on unmodified silica: O.V. Olesen & B. Poulsen; J. Chromatog.
622, 39 (1993),
Abstract;
