Replaces Prod. #: ALX-450-012
A potassium ionophore. Induces mitochondrial swelling. Induces apoptosis in CHO cells and other cell lines. Antagonizes endothelin-induced vasoconstriction (IC50=0.3µM).
Product Details
| Formula: | C54H90N6O18 |
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| MW: | 1111.3 |
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| Source: | Isolated from Streptomyces fulvissimus |
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| CAS: | 2001-95-8 |
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| Purity: | ≥97% (TLC), ≥92% (HPLC) |
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| Appearance: | White crystalline solid. |
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| Solubility: | Soluble in 100% ethanol (50mg/ml), acetic acid, chloroform, DMSO or ether. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples: J.O. Watzlawik, et al.; Autophagy
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Abstract;
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Cyclosporin A does not protect the disruption of the inner mitochondrial membrane potential induced by potassium ionophores in intact K562 cells: L.F. Marques-Santos, et al.; Cell Biol. Int.
30, 197 (2006),
Abstract;
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78: I.-J. Ryoo, et al.; Biol. Pharm. Bull.
29, 817 (2006),
Abstract;
Valinomycin-induced apoptosis in Chinese hamster ovary cells: R. Abdalah, et al.; Neurosci. Lett.
405, 68 (2006),
Abstract;
Valinomycin-induced apoptosis of human NK cells is predominantly caspase independent: A. Paananen, et al.; Toxicology
212, 37 (2005),
Abstract;
Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification: I.J. Furlong, et al.; Cell Death Differ.
5, 214 (1998),
Abstract;
Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential: Y. Inai, et al.; Cell. Struct. Funct.
22, 555 (1997),
Abstract;
Combination of the electrogenic ionophores, valinomycin and CCCP, can lead to non-electrogenic K+/H+ exchange on bilayer lipid membranes: V.N. Orlov, et al.; FEBS Lett.
345, 104 (1994),
Abstract;
K+ ionophores inhibit nerve growth factor-induced neuronal differentiation in rat adrenal pheochromocytoma PC12 cells: H. Harada, et al.; Biochim. Biophys. Acta
1220, 310 (1994),
Abstract;
The effect of respiration on the permeability of the mitochondrial membrane to ions: S. Luvisetto, et al.; Biochim. Biophys. Acta
1186, 12 (1994),
Abstract;
Alternative pathways of apoptosis induced by methylprednisolone and valinomycin analyzed by flow cytometry: C.L. Deckers, et al.; Exp. Cell. Res.
208, 362 (1993),
Abstract;
Comparison of effects of a potassium channel opener BRL34915, a specific potassium ionophore valinomycin and calcium channel blockers on endothelin-induced vascular contraction: S. Kim, et al.; Biochem. Biophys. Res. Commun.
164, 1003 (1989),
Abstract;
Valinomycin-based K+ selective microelectrodes with low electrical membrane resistance: D. Ammann, et al.; Neurosci. Lett.
74, 221 (1987),
Abstract;
Opposing interactions of ionophores (valinomycin and monensin) on calcium ion uptake in rat retinal preparations: J.B. Lombardini; Neurochem. Res.
10, 77 (1985),
Abstract;
Biological applications of ionophores: B.C. Pressman; Annu. Rev. Biochem.
45, 501 (1976),
Abstract;
