Replaces Prod. #: ALX-380-242
Chaetocin, an antitumor antibiotic, is a thiodioxopiperazine natural product produced by Chaetomium species. Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.
Product Details
| Formula: | C30H28N6O6S4 |
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| MW: | 696.9 |
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| Source: | Isolated from Chaetomium sp. |
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| CAS: | 28097-03-2 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Arsenic silences hepatic PDK4 expression through activation of histone H3K9 methylatransferase G9a: X. Zhang, et al.; Toxicol. Appl. Pharmacol.
304, 42 (2016),
Application(s): Cell culture,
Abstract;
The anticancer effect of chaetocin is enhanced by inhibition of autophagy: H. J. Jung, et al.; Cell Death Dis.
7, e2098 (2016),
Application(s): Cell culture,
Abstract;
Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress: C.R. Isham, et al.; Blood
109, 2579 (2007),
Abstract;
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9: D. Greiner, et al.; Nat. Chem. Biol.
1, 143 (2005),
Abstract;
[Isolation and configuration of Chaetocin]: D. Hauser, et al.; Helv. Chim. Acta.
53, 1061 (1970), (Article in German),
Abstract;
