Inhibits supercoiling activity of gyrase by binding to the gyrase B domain – but more importantly is a novel cell permeable dimerizing ligand for gyrase B fusion proteins. Has been used to dimerize a variety of signaling proteins such as Raf1, JAK2, Tyk and L-selectin.
Product Details
| Formula: | C55H59N5O20 |
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| MW: | 1110.1 |
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| CAS: | 4434-05-3 |
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| Purity: | ≥97% (TLC) |
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| Identity: | Determined by IR. |
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| Appearance: | White to light yellow solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A Novel Function of eIF2α Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway: S. Kazemi, et al.; Mol. Biol. Cell
18, 3635 (2007),
Abstract;
Activation and functional analysis of Janus kinase 2 in BA/F3 cells using the coumermycin/gyrase B system: M. G. Mohi et al.; Mol. Biol. Cell.
912, 3299 (1998),
Abstract;
Conditional activation of Janus kinase (JAK) confers factor independence upon interleukin-3-dependent cells. Essential role of Ras in JAK-triggered mitogenesis: R. Mizuguchi et al.; J. Biol. Chem.
273, 32297 (1998),
Abstract;
Regulation of L-selectin-mediated rolling through receptor dimerization: X. Li et al.; J. Exp. Med.
188, 1385 (1998),
Abstract;
The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin: F. T. Farrar et al.; Proteins
28, 41 (1997),
Abstract;
Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization: M. A. Farrar et al.; Nature
383, 178 (1996),
Abstract;
