Replaces Prod. #: ALX-380-097
Mithramycin noncovalently interacts with G-C-rich duplex DNA in the presence of Mg2+ or Zn2+. It induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression. It selectively inhibits collagen-1 gene expression in human fibroblasts.
Product Details
| Alternative Name: | Plicamycin |
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| Formula: | C52H76O24 |
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| MW: | 1085.1 |
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| Source: | Isolated from Streptomyces argillaceus |
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| CAS: | 18378-89-7 |
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| MI: | 14: 7536 |
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| Purity: | ≥95% (HPLC, TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in phosphate buffered saline (1mg/ml), 100% ethanol, DMSO or methanol |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells: E. Im, et al.; Life Sci.
192, 286 (2018),
Abstract;
Early activation of Egr-1 promotes neuroinflammation and dopaminergic neurodegeneration in an experimental model of Parkinson's disease: Q. Yu, et al.; Exp. Neurol.
302, 145 (2018),
Abstract;
Mithramycin A activates Fas death pathway in leukemic cell lines: I. Leroy, et al.; Apoptosis
11, 113 (2006),
Abstract;
Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression: S.Y. Ahn, et al.; Am. J. Pathol.
164, 1663 (2004),
Abstract;
Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3: M.A. Mir, et al.; Bioorg. Med. Chem.
11, 2791 (2003),
Abstract;
Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast: M.C. Nehls, et al.; J. Clin. Invest.
92, 2916 (1993),
Abstract;
Interaction of mithramycin with DNA. Evidence that mithramycin binds to DNA as a dimer in a right-handed screw conformation: C. Demicheli, et al.; Eur. J. Biochem.
198, 333 (1991),
Abstract;
Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene: R. Ray, et al.; Am. J. Med. Sci.
300, 203 (1990),
Abstract;
Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea: C.A. Koller & D.M. Miller; N. Engl. J. Med.
315, 1433 (1986),
Abstract;
Chromomycin A3, mithramycin, and olivomycin: antitumor antibiotics of related structure: M. Slavik & S.K. Carter; Adv. Pharmacol. Chemother.
12, 1 (1975),
Abstract;
Aureolic acid group of anti-tumour antibiotics: Y.U. Berlin, et al.; Nature
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Abstract;
