Replaces Prod. #: ALX-340-029
Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].
Product Details
| Alternative Name: | AEA, N-Arachidonoylethanolamine, (all-Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide |
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| Formula: | C22H37NO2 |
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| MW: | 347.54 |
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| CAS: | 94421-68-8 |
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| MI: | 14: 624 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Colorless oil. |
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| Solubility: | Soluble in ethanol (e.g. at a concentration of 50 mg/ml). It is also soluble in DMSO and dimethyl formamide. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, under an inert atmosphere at -80°C. |
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| Handling: | Protect from light and oxygen. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes: J. Joseph, et al.; Cancer Immunol. Immunother.
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Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways: V.A. Movsesyan, et al.; Cell Death Differ.
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The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation: L. De Petrocellis, et al.; PNAS
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