Inhibits ergosterol biosynthesis at the level of squalene epoxidase. Potent non-competitive inhibitor of squalene epoxidase from Candida (Ki=30 nM), inhibiting mammalian enzymes at higher concentrations (4-77 µM). It inhibits HUVEC proliferation and angiogenesis and displays interesting anti-inflammatory and free radical scavenging activities. Clinically useful antifungal agent.
Product Details
| Alternative Name: | trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine . hydrochloride |
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| Formula: | C21H25N . HCl |
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| MW: | 327.9 |
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| CAS: | 78628-80-5 |
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| Purity: | ≥98% (UHPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in ethanol (45 mg/ml), DMSO (30 mg/ml) or water (3 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition of human vascular endothelial cells proliferation by terbinafine: P. Y. Ho, et al.; Int. J. Cancer
111, 51 (2004),
Abstract;
Inhibitory effect of terbinafine on reactive oxygen species (ROS) generation by Candida albicans: C. S. Sander, et al.; Mycoses
45, 152 (2002),
Abstract;
Anti-inflammatory activity of antifungal preparations: T. Rosen, et al.; Int. J. Dermatol.
36, 788 (1997),
Abstract;
Differential inhibition of fungal amd mammalian squalene epoxidases by the benzylamine SDZ SBA 586 in comparison with the allylamine terbinafine: B. Favre, et al.; Arch. Biochem. Biophys.
340, 265 (1997),
Abstract;
Terbinafine: mode of action and properties of the squalene epoxidase inhibition: N. S. Ryder, et al.; Br. J. Dermatol.
126, 39 (1992),
Abstract;
