Ikarugamycin inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages. It blocks PMA and Nef-mediated cell surface CD4 down-regulation. Ikarugamycin is emerging as a general inhibitor of clathrin-coated pit-mediated endocytosis and appears to be a useful agent for studying the process of endocytosis.
Product Details
| Formula: | C29H38N2O4 |
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| MW: | 478.6 |
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| CAS: | 36531-78-9 |
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| Purity: | ≥95% (HPLC, TLC) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in DMFA, DMSO or THF. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Distinct endocytic pathways identified in tobacco pollen tubes using charged nanogold: A. Moscatelli, et al.; J. Cell. Sci.
120, 3804 (2007),
Abstract;
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Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin: T. Luo, et al.; J. Virol.
75, 2488 (2001),
Abstract;
Full Text
Inhibition of the uptake of oxidized low-density lipoprotein in macrophage J774 by the antibiotic ikarugamycin: K. Hasumi, et al.; Eur. J. Biochem.
205, 841 (1992),
Abstract;
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