Replaces Prod. #: ALX-270-197
Cyclooxygenase inhibitor. Selectively inhibits PGH synthase-2 (IC50=1 µM) with no inhibition of PGH synthase-1 at concentrations up to 100 µM. Protects neuronal cultures from LPS-induced neurotoxicity.
Product Details
| Alternative Name: | N-[2-(Cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide |
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| Formula: | C13H18N2O5S |
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| MW: | 314.4 |
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| CAS: | 123653-11-2 |
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| Purity: | ≥98% (HPLC) |
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| Solubility: | Soluble in 100% ethanol (warm; sonication), DMSO (25mg/ml) or dimethyl formamide. Insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Feline adipose tissue-derived mesenchymal stem cells pretreated with IFN-γ enhance immunomodulatory effects through the PGE2 pathway: S.G. Park, et al.; J. Vet. Sci.
22, e16 (2021),
Application(s): Feline adipose-tissue derived (fAT)-MSCs treatment,
Abstract;
Full Text
Prostaglandin E2 secreted from feline adipose tissue-derived mesenchymal stem cells alleviate DSS-induced colitis by increasing regulatory T cells in mice: J.H. An, et al.; BMC Vet. Res.
14, 354 (2018),
Abstract;
Full Text
Hypoxia potentiates tumor necrosis factor-α induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in white and brown adipocytes: I. Bhattacharya, et al.; Biochem. Biophys. Res. Commun.
461, 287 (2015),
Application(s): Cell Culture,
Abstract;
Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism: M.C. Zatelli, et al.; J. Clin. Endocrinol. Metab.
90, 5754 (2005),
Abstract;
Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): rationale for selective inhibition and progress to date: D.E. Griswold & J.L. Adams; Med. Res. Rev.
16, 181 (1996),
Abstract;
Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms: M. Ouellet & M.D. Percival; Biochem. J.
306, 247 (1995),
Abstract;
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase: J.K. Gierse, et al.; Biochem. J.
305 (Pt 2), 479 (1995),
Abstract;
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys.
324, 26 (1995),
Abstract;
Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase: R.A. Copeland, et al.; PNAS
91, 11202 (1994),
Abstract;
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins
47, 55 (1994),
Abstract;
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system: J. Barnett, et al.; Biochim. Biophys. Acta
1209, 130 (1994),
Abstract;
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic: J.L. Masferrer, et al.; PNAS
91, 3228 (1994),
Abstract;
Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats: I. Arai, et al.; Res. Commun. Chem. Pathol. Pharmacol.
81, 259 (1993),
Abstract;
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions: N. Futaki, et al.; Gen. Pharmacol.
24, 105 (1993),
Abstract;
