Replaces Prod. #: ALX-350-029
Antibiotic. Cell permeable tyrosine kinase inhibitor. It is effective on Src, Yes, Fps, Ros, Abl and ErbB oncogene products and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C. It also inhibits HSP90, NF-κB activation and angiogenesis. Increases the sensitivity of certain cancer cells to chemotherapeutic agents. Blocks mitotic activity. Neurotoxic.
Product Details
| Formula: | C30H42N2O9 |
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| MW: | 574.7 |
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| CAS: | 70563-58-5 |
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| RTECS: | LX8930000 |
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| Formulation: | Lyophilized. |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in ethanol, methanol, DMF or DMSO. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
TNFα-induced airway smooth muscle cell proliferation depends on endothelin receptor signaling, GM-CSF and IL-6: J. Knobloch, et al.; Biochem. Pharmacol.
2952, 30173 (2016),
Application(s): HASMC count - human bronchus tissue,
Abstract;
Herbimycin A suppresses mitotic activity and egg production of female Schistosoma mansoni: J. Knobloch, et al.; Int. J. Parasitol.
36, 1261 (2006),
Abstract;
Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells’ sensitivity to cytotoxic drugs: D.T. Jones, et al.; Blood
103, 1855 (2004),
Abstract;
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Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit: S. Ogino, et al.; Mol. Pharmacol.
65, 1344 (2004),
Abstract;
Full Text
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs: M.V. Blagosklonny; Leukemia
16, 455 (2002),
Abstract;
Full Text
Herbimycin A enhances apoptotic effect of chemotherapeutic drugs on K562 cells: H. Ren, et al.; Chin. Med. J. (Engl.)
111, 678 (1998),
Abstract;
Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy: T.-P.D. Fan, et al.; TIPS
16, 57 (1995), (Review),
Abstract;
Inhibition of PDGF-induced phospholipase D but not phospholipase C activation by herbimycin A: B.Y. Kim; BBRC
212, 1061 (1995),
Abstract;
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation: L. Whitesell, et al.; PNAS
91, 8324 (1994),
Abstract;
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Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors: K. Migita, et al.; J. Immunol.
153, 3457 (1994),
Abstract;
New insight into oncoprotein-targeted antitumor effect: herbimycin A as an antagonist of protein tyrosine kinase against Ph1-positive leukemia cells: M. Okabe and M. Uehara; Leuk. Lymphoma
12, 41 (1993),
Abstract;
Inhibition of interleukin 3 and granulocyte-macrophage colony- stimulating factor stimulated increase of active ras.GTP by herbimycin A, a specific inhibitor of tyrosine kinases: T. Satoh, et al.; J. Biol. Chem.
267, 2537 (1992),
Abstract;
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Inhibition of tyrosine phosphorylation prevents thrombin-induced mitogenesis, but not intracellular free calcium release, in vascular smooth muscle cells: R.H. Weiss & R. Nuccitelli; J. Biol. Chem.
267, 5608 (1992),
Abstract;
Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages: S.L. Weinstein, et al.; PNAS
88, 4148 (1991),
Abstract;
IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells: D.J. Park, et al.; J. Biol. Chem.
266, 24237 (1991),
Abstract;
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Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro: H. Fukazawa, et al.; Biochem. Pharmacol.
42, 1661 (1991),
Abstract;
Stimulation by Bt2cAMP of epidermal mucous metaplasia in retinol- pretreated chick embryonic cultured skin, and its inhibition by herbimycin A, an inhibitor for protein-tyrosine kinase: A. Obinata, et al.; Exp. Cell. Res.
193, 36 (1991),
Abstract;
Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases: Y. Uehara & H. Fukazawa; Methods Enzymol.
201, 370 (1991),
Abstract;
A new activity of herbimycin A: inhibition of angiogenesis: T. Yamashita, et al.; J. Antibiot. (Tokyo)
42, 1015 (1989),
Abstract;
Herbimycin, a new antibiotic produced by a strain of Streptomyces: S. Omura, et al.; J. Antibiot. (Tokyo)
32, 255 (1979),
Abstract;
