Replaces Prod. #: ALX-270-113
Flavonoid. Protein kinase C (PKC) inhibitor. PGF2a receptor antagonist. In astrocytes, these receptors are linked to phospholipase C, thus affecting phosphoinositide hydrolysis and intracellular Ca2+ levels. Inhibits myo-inositol uptake and 5’-iodothyronine deiodinase. Prevents TNF-α stimulated upregulation of VCAM-1, ICAM-1 and E-selectin. Enhances adiponectin expression.
Product Details
| Formula: | C15H14O5 |
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| MW: | 274.3 |
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| CAS: | 60-82-2 |
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| MI: | 14: 7326 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | Off-white to beige solid. |
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| Solubility: | Soluble in acetone, DMSO, 100% ethanol or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Product may air oxidize in solution. Make solutions fresh daily. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells: M. Hassan, et al.; BBRC
361, 208 (2007),
Abstract;
The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets: V. Stangl, et al.; J. Nutr.
135, 172 (2005),
Abstract;
Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae: T. Kasahara & M. Kasahara; Biochem. J.
315 (Pt1), 177 (1996),
Abstract;
Functional differentiation of the human red blood cell and kidney urea transporters: S. Martial, et al.; Am. J. Physiol.
271, F1264 (1996),
Abstract;
Activating effect of the flavonoid phloretin on Ca(2+)-activated K+ channels in myelinated nerve fibers of Xenopus laevis: D.S. Koh, et al.; Neurosci. Lett.
165, 167 (1994),
Abstract;
Cloning and functional expression of a urea transporter from human bone marrow cells: B. Olives, et al.; J. Biol. Chem.
269, 31649 (1994),
Abstract;
Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C: N. Prevarskaya, et al.; Mol. Cell. Neurosci.
5, 699 (1994),
Abstract;
The effect of glucose and galactose toxicity on myo-inositol transport and metabolism in human skin fibroblasts in culture: G.T. Berry, et al.; Pediat. Res.
35, 141 (1994),
Abstract;
Thyroid hormones in tissues from fetal and adult rats: G. Morreale de Escobar; Endocrinology
134, 2410 (1994),
Abstract;
Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells: X. Wang, et al.; Biochem. J.
290, 249 (1993),
Abstract;
Cloning and characterization of the vasopressin-regulated urea transporter: G. You, et al.; Nature
365, 844 (1993),
Abstract;
Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes: J. Kitanaka, et al.; J. Neurochem.
60, 704 (1993),
Abstract;
Effects on water diffusion of inhibitors affecting various transport processes in human red blood cells: G. Benga, et al.; Eur. J. Cell Biol.
59, 219 (1992),
Abstract;
Calcium and phospholipid-dependent protein kinase activity in mouse epidermis cytosol. Stimulation by complete and incomplete tumor promoters and inhibition by various compounds: M. Gschwendt, et al.; BBRC
124, 63 (1984),
Abstract;
