Shikonin inhibits TNF-α- and B6 melanoma-induced angiogenesis in mice. It blocks expression of integrin αvβ3 and inhibits endothelial cell proliferation and migration in vitro.
Product Details
| Formula: | C16H16O5 |
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| MW: | 288.3 |
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| Source: | Shikonin is a napthoquinone isolated from the roots of Lithospermum erythrorhizon; a component of the traditional Chinese herbal remedy Shiunko. |
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| CAS: | 517-89-5 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by NMR and MS. |
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| Appearance: | Red crystalline solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Nephropreventive Effect of Shikonin on Murine LPS-induced Septic Acute Kidney: M. Kawara, et al.; J. Clin. Exp. Nephrol.
1, 19 (2016),
Application(s): In vivo murine administration,
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Cytotoxicity of natural products and derivatives towards MCF-7 cell monolayers and cancer stem-like mammospheres: E.J. Seo, et al.; Phytomedicine
22, 438 (2015),
Application(s): Flow Cytometry,
Abstract;
A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases: K. Nigorikawa, et al.; Mol. Pharmacol.
70, 1143 (2006),
Abstract;
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p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells: Z. Wu, et al.; J. Pharmacol. Sci.
94, 166 (2004),
Abstract;
Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro: T. Hisa, et al.; Anticancer Res.
18, 783 (1998),
Abstract;
