Replaces Prod. #: ALX-380-058
Antibiotic. Induces mitochondrial permeability pore opening and inhibits respiration by interfering with complex I of the respiratory chain. Mycotoxin. Acts as nephrotoxin in all species in which it has been tested. Has been implicated as a cause of Balkan nephropathy and yellow rice fever in humans. Induces apoptosis.
Product Details
| Formula: | C13H14O5 |
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| MW: | 250.2 |
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| Source: | Isolated from Penicillium citrinum |
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| CAS: | 518-75-2 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | Yellow crystalline solid. |
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| Solubility: | Soluble in 100% ethanol, methylene chloride (10mg/ml), methanol, dioxane, pyridine or dichlormethane. Insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9). |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts: W.H. Chan ; Biochem. J.
404, 317 (2007),
Abstract;
Citrinin induces apoptosis in HL-60 cells via activation of the mitochondrial pathway: F.Y. Yu et al.; Toxicol. Lett.
161, 143 (2006),
Abstract;
Clin Microbiol Rev: J.W. Bennett & M. Klich; Clin. Microbiol. Rev.
16, 497 (2003),
Abstract;
Citrinin-induced mitochondrial permeability transition: E:J. Da Lozzo et al.; J Biochem Mol Toxicol
12, 291 (1998),
Abstract;
Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling: G.M. Chagas et al.; J. Appl. Toxicol.
15, 91 (1995),
Abstract;
