Replaces Prod. #: ALX-430-106
Active metabolite of sulindac (Prod. No. ALX-430-105). Inhibits cyclooxygenase. More selective for PGHS-1 (ID50=0.5 µM) over PGHS-2 (ID50=14 µM). Induces apoptosis by a cyclooxygenase-independent mechanism. Inhibits colorectal cancer growth and γ-secretase. NF-κB inhibitor. Inhibits Ras signaling.
Product Details
Alternative Name: | Z-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid |
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Formula: | C20H17FO2S |
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MW: | 340.4 |
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CAS: | 32004-67-4 |
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Purity: | ≥99% (TLC) |
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Appearance: | Yellow-orange solid. |
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Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (5mg/ml, warm). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | Ambient |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
PKGI mediates the growth inhibitory effects of cGMP signaling in human breast cancer cells independent of β-catenin: P.F. Windham, et al.; Integr. Cancer Sci. Therap.
2, 185 (2015),
Application(s): Western Blot,
Full Text
Sulindac inhibits activation of the NF-kappaB pathway: Y. Yamamoto, et al.; J. Biol. Chem.
274, 27307 (1999),
Abstract;
Sulindac sulfide inhibits Ras signaling: C. Herrmann, et al.; Oncogene
17, 1769 (1998),
Abstract;
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis: G.A. Piazza, et al.; Cancer Res.
55, 3110 (1995),
Abstract;
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs: E.A. Meade, et al.; J. Biol. Chem.
268, 6610 (1993),
Abstract;