Replaces Prod. #: ALX-480-039
Potent inhibitor of inducible nitric oxide synthase (iNOS; NOS II) in mouse macrophages. Potent and selective PARP inhibitor. Inhibits nitric oxide (SIN-1) induced PARP activation in rat hepatocytes (at 20µM). Neuroprotectant.
Product Details
| Formula: | C9H7NO2 |
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| MW: | 161.2 |
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| CAS: | 5154-02-9 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/ml), dimethyl formamide (25mg/ml) or 100% ethanol (25mg/ml warm). Also soluble in 0.1N NaOH or in methanol; insoluble in water and 0.1N HCl. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors
9, 173 (2016),
Application(s): Potency of inhibitors,
Abstract;
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Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients: K. Obermeier, et al.; Oncogene
35, 3796 (2016),
Abstract;
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell
32, 57 (2008),
Abstract;
Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol.
57, 109 (2006),
Abstract;
All trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor: D.M. Berry, et al.; Leuk. Res.
24, 307 (2000),
Abstract;
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock: M.C. McDonald, et al.; Br. J. Pharmacol.
128, 1339 (1999),
Abstract;
Inhibition of poly(ADP-ribose)polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts: A. Semionov, et al.; Nucleic Acids Res.
27, 4526 (1999),
Abstract;
Nitric oxide inhibits DNA synthesis and induces activation of poly(ADP-ribose) polymerase in cultured rat hepatocytes: M. Dalmau, et al.; Exp. Cell Res.
228, 14 (1996),
Abstract;
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science
263, 687 (1994),
Abstract;
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem.
267, 1569 (1992),
Abstract;
