Replaces Prod. #: ALX-270-250
Potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) (IC50=0.18μM). Reduces ischemia-reperfusion injury in the heart and skeletal muscle.
Product Details
| Alternative Name: | 4-ANI |
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| Formula: | C12H8N2O2 |
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| MW: | 212.2 |
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| CAS: | 1742-95-6 |
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| Purity: | ≥96% (NMR) |
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| Appearance: | Orange solid. |
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| Solubility: | Soluble in DMSO (5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors
9, 173 (2016),
Application(s): Potency of inhibitors,
Abstract;
Full Text
The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells: Q. Luo, et al.; J. Toxicol. Sci.
40, 349 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors: C.C. Chini, et al.; Clin. Cancer Res.
20, 120 (2014),
Abstract;
4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer: A. Schlicker, et al.; Int. J. Radiat. Biol.
75, 91 (1999),
Abstract;
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: a comparison with radical scavengers: J. Bowes & C. Thiemermann; Br. J. Pharmacol.
124, 1254 (1998),
Abstract;
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle: C. Thiemermann, et al.; Proc. Natl. Acad. Sci. USA
94, 679 (1997),
Abstract;
Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin: F. Bernges, et al.; J. Cancer Res. Clin. Oncol.
122, 665 (1996),
Abstract;
Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion: J. Radons, et al.; Biochem. Biophys. Res. Commun.
199, 1270 (1994),
Abstract;
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem.
267, 1569 (1992),
Abstract;
