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Ascomycin

Immunosuppressant



BML-A165-0001	1 mg	247.00 USD
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Replaces Prod. #: ALX-380-005

Ascomycin is a close structural analog of FK506 and is a potent immunosuppressant. It binds to FKBP (FK506-binding protein) and suppresses its proline rotamase activity. The ascomycin-FKBP complex inhibits calcineurin, a type 2B phosphatase.

Product Details

Alternative Name:	Immunomycin

Formula:	C₄₃H₆₉NO₁₂

MW:	792

Source:	Isolated from Streptomyces sp.

CAS:	104987-12-4; also registered as 11011-38-4

Purity:	≥90% (HPLC, TLC)

Appearance:	Off-white solid

Solubility:	Soluble in DMSO, methanol or ethanol.

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Use/Stability:	Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Experiences from using LC-MS/MS for analysis of immunosuppressive drugs in a TDM service: A. Pohanka, et al.; Clin. Biochem. 49, 1024 (2016), Application(s): Rapid chromatography and co-elution, Abstract;

Biosynthetic studies of ascomycin (FK520): Formation of the (1R,3R,4R)-3,4-dihydroxycyclohexanecarboxylic acid-derived moiety: K.K. Wallace, et al.; J. Am. Chem. Soc. 116, 11600 (1994), Abstract;

Cyclosporin A, FK506 and rapamycin: more than just immunosuppression: J. Kunz & M.N. Hall; Trends. Biochem. Sci. 18, 334 (1993), Abstract;

Enzymatic synthesis and immunosuppressive activity of novel desmethylated immunomycins (ascomycins): A. Shafiee, et al.; J. Antibiot. (Tokyo) 46, 1397 (1993), Abstract;

FK506 and ciclosporin: molecular probes for studying intracellular signal transduction: J. Liu, et al.; Trends Pharmacol. Sci. 14, 182 (1993), Abstract;

Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues: M. Kawai, et al.; FEBS Lett. 316, 107 (1993), Abstract;

NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein: A.M. Petros, et al.; J. Med. Chem. 35, 2467 (1992), Abstract;

Ascomycin, an antifungal antibiotic: T. Arai, et al.; J. Antibiot. (Tokyo) 15, 231 (1962), Abstract;