Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.
Product Details
| Alternative Name: | TNFRSF 5 |
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| Clone: | FGK45 |
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| Host: | Rat |
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| Isotype: | IgG2a |
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| Immunogen: | Recombinant mouse CD40 fusion protein. |
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| UniProt ID: | P27512 |
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| Source: | Purified from hybridoma tissue culture supernatant. |
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| Species reactivity: | Mouse
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| Applications: | ELISA, Flow Cytometry, WB, FUNC
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| Application Notes: | Functional Application: activates B and NK cells in vivo and in vitro. |
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2: T. Nguyen, et al.; J. Exp. Med.
220, e20221020. (2023),
Abstract;
ATAD5 deficiency decreases B cell division and Igh recombination: K.J. Zanotti, et al.; J. Immunol.
194, 32 (2015),
Abstract;
CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema: A. Shigeta, et al.; Am. J. Physiol. Lung Cell. Mol. Physiol.
303, L141 (2012),
Abstract;
Full Text
Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific CD4+ T cell proliferation during the induction of inhalation tolerance: V.S. Fear, et al.; J. Immunol.
187, 4561 (2011),
Abstract;
Full Text
Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs): H. Yanai, et al.; PNAS
108, 11542 (2011),
Abstract;
Full Text
A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity: W.A. Schroder, et al.; J. Immunol.
184, 2663 (2010),
Abstract;
Full Text
Expression of Cellular FLIP by B Cells Is Required for Their Participation in an Immune Response: F. Coffey & T. Manser; J. Immunol.
184, 4871 (2010),
Abstract;
Full Text
Identification and characterization of a lupus suppressor 129 locus on chromosome 3: F. Carlucci, et al.; J. Immunol.
184, 6255 (2010),
Abstract;
Full Text
The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression: T.T. Zhang, et al.; J. Immunol.
184, 164 (2010),
Abstract;
Full Text
A role for cFLIP in B cell proliferation and stress MAPK regulation: H. Zhang, et al.; J. Immunol.
182, 207 (2009),
Abstract;
Full Text
Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus: C. Bartholdy, et al.; J. Immunol.
178, 1662 (2007),
Abstract;
IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling: P.W. Hellings, et al.; J. Immunol.
177, 5138 (2006),
Abstract;
In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN: J.A. Greene, et al.; J. Immunol.
176, 5995 (2006),
Abstract;
Regulatory and effector T cell activation levels are prime determinants of in vivo immune regulation: F. Billiard, et al.; J. Immunol.
177, 2167 (2006),
Abstract;
Full Text
IRF-7 is the master regulator of type-I interferon-dependent immune responses: K. Honda, et al.; Nature
434, 772 (2005),
Abstract;
CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes: C.M. McGregor, et al.; PNAS
101, 9345 (2004),
Abstract;
Full Text
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system: A. Erlebacher, et al.; J. Clin. Invest.
114, 39 (2004),
Abstract;
Full Text
The antigen-presenting activity of fresh, adult parenchymal microglia and perivascular cells from retina: D.S. Gregerson, et al.; J. Immunol.
172, 6587 (2004),
Abstract;
Full Text
Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells: J.G. Turner, et al.; J. Immunol.
166, 89 (2001),
Abstract;
Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process: C. Mauri, et al.; Nat. Med.
6, 673 (2000),
Abstract;
Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity: A.G. Rolink, et al.; Eur. J. Immunol.
28, 3738 (1998),
Abstract;
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching: A. Rolink, et al.; Immunity
5, 319 (1996),
Abstract;
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