Fas (human) monoclonal antibody (APO-1-1)



ALX-805-022-C100	100 µg	Purified	405.00 USD
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Product Details

Alternative Name:	CD95, APO-1, TNFRSF 6

Clone:	APO-1-1

Host:	Mouse

Isotype:	IgG1

Immunogen:	Human Fas (CD95; APO-1).

UniProt ID:	P25445

Species reactivity:	Human

Applications:	Flow Cytometry, IHC (FS), FUNC

Recommended Dilutions/Conditions:	Flow Cytometry (1-2µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Application Notes:	APO-1-1 (IgG1) is an isotype-switch variant of the original clone APO-1-3 (ALX-805-020). Since undesired side reactions in immunohistochemistry are minimal for IgG1 antibodies, APO-1-1 is especially useful for immunohistology on cryostat sections and on cytospin preparations. Not suitable for stainings on paraffin sections. Functional Application: Induces apoptosis upon cross-linking.

Formulation:	Liquid. In PBS, pH 7.2-7.4.

Handling:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Shipping:	Blue Ice

Long Term Storage:	+4°C

Regulatory Status:	RUO - Research Use Only

Product Literature References

Cytotoxic efficiency of human CD8+ T cell memory subtypes: A. Knörck, et al.; Front. Immunol. 13, 838484 (2022), Abstract; Full Text

Epigenetically Enhanced PDT Induces Significantly Higher Levels of Multiple Extrinsic Pathway Apoptotic Factors than Standard PDT, Resulting in Greater Extrinsic and Overall Apoptosis of Cutaneous T-cell Lymphoma: K.A. Salva, et al.; Photochem. Photobiol. 94, 1058 (2018), Application(s): Multispectral imaging of immunostained cytopreparations, Abstract;

Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms: C.S. Backes, et al.; J. Biol. Chem. 293, 16348 (2018), Abstract; Full Text

Specific elimination of effector memory CD4+ T cells due to enhanced Fas signaling complex formation and association with lipid raft microdomains: M. Ramaswamy, et al.; Cell Death Differ. 18, 712 (2011), Abstract; Full Text

Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD): H. Wajant, et al.; J. Biol. Chem. 275, 24357 (2000), Abstract; Full Text

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L): D.C. Huang, et al.; PNAS 96, 14871 (1999), Abstract;

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells: F. Leithauser, et al.; Lab. Invest. 69, 415 (1993), Abstract;

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