| ALX-804-863-C100 | 100 µg | 467.00 USD |  |
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| Alternative Name: | Helicard, Melanoma differentiation-associated gene 5, Interferon-induced helicase C domain-containing protein 1, RH116, CADM-140 autoantigen, RIG-I-like receptor 2, RLR-2 |
| Clone: | Hely-1 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human MDA5 (melanoma differentiation-associated gene 5) (aa 78-555). |
| UniProt ID: | Q9BYX4 |
| Source: | Purified from concentrated hybridoma tissue cell culture supernatant. |
| Species reactivity: | Human |
| Applications: | ELISA, IP, WB |
| Recommended Dilutions/Conditions: | Immunoprecipitation (1:100) Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | ELISA Immunoprecipitation (1:100) Western Blot (1:1'000) |
| Purity Detail: | Protein G-affinity purified. |
| Formulation: | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Short Term Storage: | +4°C |
| Long Term Storage: | -20°C |
| Scientific Background: | MDA5 and RIG-I are highly conserved helicases involved in the innate immune response to virus. MDA-5 ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. After binding nonself-ligand, RIG-I and MDA5 interact via their CARD domains with the signaling-adaptor molecule, IPS-1 (also known as MAVS, VISA and Cardif), which leads to the induced expression of IFN-β, IRF3-target genes and NF- κB target genes to drive antiviral and inflammatory responses. |
| Regulatory Status: | RUO - Research Use Only |
MDA5 (human) polyclonal antibody (AT113) |
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| Purified from rabbit serum., IP, WB | Print as PDF | ||||||
| ALX-210-935-C100 | 100 µg | 470.00 USD | |
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MDA5 polyclonal antibody |
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| ELISA, IF, IHC (PS), WB | Print as PDF | ||||||
| ENZ-ABS299-0100 | 100 µg | 425.00 USD | |
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MDA5 monoclonal antibody (1B6) |
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| Purified from hybridoma tissue culture supernatant., ELISA, WB | Print as PDF | ||||||
| ALX-804-878-C100 | 100 µg | 353.00 USD | |
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