Product Details
| Clone: | 114C307.1 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant human Noxa. |
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| UniProt ID: | Q13794 |
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| Species reactivity: | Human, Mouse
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| Applications: | ICC, IHC (PS), WB
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| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections, 5µg/ml)
Western Blot (1-2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~11kDa by Western blot. |
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.05% sodium azide. |
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| Use/Stability: | Stable for 6 months when stored at +4°C. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Western blot detection of Noxa in RL-7 cell (a follicular lymphoma) lysate. A protein band of approximate molecular weight of ~11kDa was detected using ALX-804-408 at 2µg/ml dilution.
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Product Literature References
Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions: K. Seiler, et al.; Cell Death Dis.
13, 448 (2022),
Abstract;
Increased expression of importin-β, exportin-5 and nuclear transportable proteins in Alzheimer's disease aids anatomic pathologists in its diagnosis: G. Nuovo, et al.; Ann. Diag. Pathol.
32, 10 (2018),
Application(s): Immunohistochemistry on human brain FFPE tissue,
Abstract;
Assessment of Drug Sensitivity in Hematopoietic Stem and Progenitor Cells From Acute Myelogenous Leukemia and Myelodysplastic Syndrome Ex Vivo: K. L. Knorr, et al.; Stem Cells Transl. Med.
6, 840 (2017),
Abstract;
Full Text
Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs: M.T. Meister, et al.; Cancer Lett.
381, 287 (2016),
Application(s): Western blot analysis,
Abstract;
Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis: P. Gomez-Bougie, et al.; Cancer Lett.
383, 204 (2016),
Application(s): Immunoblotting, human myeloma cell lines,
Abstract;
MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies: G. S. Choudhary, et al.; Cell Death Dis.
6, e1593 (2015),
Application(s): Western Blotting,
Abstract;
Full Text
MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors: K.L.B. Knorr, et al.; Cell Death Differ.
22, 2133 (2015),
Application(s): Western Blot,
Abstract;
Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL: A. Meijer, et al.; Br. J. Cancer
109, 2685 (2013),
Abstract;
Full Text
Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis: S. Ying, et al.; Infect. Immun.
73, 1399 (2005),
Abstract;
Full Text
BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis: A.G. Yakovlev, et al.; J. Biol. Chem.
279, 28367 (2004),
Abstract;
Full Text
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation: S. Erster, et al.; Mol. Cell. Biol.
24, 6728 (2004),
Abstract;
Full Text
p53 has a direct apoptogenic role at the mitochondria: M. Mihara, et al.; Mol. Cell
11, 577 (2003),
Abstract;
Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage: B.E. Deverman, et al.; Cell
111, 51 (2002),
Abstract;
