Product Details
Clone: | C7-50 |
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Host: | Mouse |
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Isotype: | IgG1 |
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Immunogen: | Purified HCV (hepatitis C virus) core fusion protein (genotype 1b). |
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Species reactivity: | Hepatitis C virus
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Specificity: | Recognizes an epitope between aa 21-40 of HCV core protein. This sequence is conserved among different HCV strains. |
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Applications: | ELISA, ICC, IP, WB
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Recommended Dilutions/Conditions: | Western Blot (1µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Immunocytochemical staining of HCV core protein in transfected chimp hepatocytes yields a staining pattern consistent with cytoplasmic and vesicular staining.
Detects a band of ~21kDa by Western blot. |
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Formulation: | Liquid. In PBS containing 0.05% sodium azide. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Hepatitis C virus (HCV) is the primary cause of non-A, non-B hepatitis and results in most HCV-infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. The 21kDa core protein of HCV is well conserved among different HCV genotypes and may suppress hepatitis B virus replication in a phosphorylation dependent manner. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Infection of Human Liver Myofibroblasts by Hepatitis C Virus: A Direct Mechanism of Liver Fibrosis in Hepatitis C: L. Aoudjehane, et al.; PLoS One
10, e0134141 (2015),
Application(s): Western blot ,
Abstract;
Full Text
Characterization of three novel monoclonal antibodies against hepatitis C virus core protein: D. Moradpour, et al.; J. Med. Virol.
48, 234 (1996),
Abstract;