Product Details
| Alternative Name: | ODF, TRANCE, OPGL, TNFSF 11, CD254 |
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| Clone: | 12A668 |
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| Host: | Mouse |
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| Isotype: | IgG1 κ |
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| Immunogen: | Recombinant mouse RANKL (aa 1-317). |
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| UniProt ID: | O35235 |
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| Species reactivity: | Human, Mouse
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| Applications: | IHC (PS), WB
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| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections, 5µg/ml)
Western Blot (1-2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~35-40kDa by Western blot.
Not suitable for flow cytometry. |
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Use/Stability: | Stable for 6 months when stored at +4°C. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | Replacement for ADI-AAM-425, see also ADI-AAM-425AF |
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| Regulatory Status: | RUO - Research Use Only |
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Figure 1: Western blot analysis of RANKL in transfected cells using MAb to RANKL (12A668) (Prod. No.
ALX-804-243)."
Figure 2: Immunohistochemical staining of RANKL in formalin-fixed, paraffin embedded human lymph node using MAb to RANKL (Prod. No.
ALX-804-243) at 5μg/ml. Hematoxylin-eosin counterstain."
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Product Literature References
Astaxanthin Protects against Hyperglycemia-Induced Oxidative and Inflammatory Damage to Bone Marrow and to Bone Marrow-Retained Stem Cells and Restores Normal Hematopoiesis in Streptozotocin-Induced Diabetic Mice: G. Bhattarai, et al.; Antioxidants
11, 2321 (2022),
Abstract;
Astaxanthin Inhibits Diabetes-Triggered Periodontal Destruction, Ameliorates Oxidative Complications in STZ-Injected Mice, and Recovers Nrf2-Dependent Antioxidant System: G. Bhattarai, et al.; Nutrients
13, 3575 (2021),
Abstract;
Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor: S. Niida, et al.; J. Biol. Chem.
279, 5752 (2004),
Abstract;
Full Text
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines: P. Fiumara, et al.; Blood
98, 2784 (2001),
Abstract;
Full Text
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors: T. Kikuchi, et al.; J. Immunol.
166, 3574 (2001),
Abstract;
Full Text
Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression: R.N. Pearse, et al.; PNAS
98, 11581 (2001),
Abstract;
Full Text
