Product Details
| Alternative Name: | RICK, CARDIAK, CARD-containing interleukin-1β converting enzyme associated kinase, RIPK2, Receptor-interacting serine/threonine protein kinase 2, Receptor-interacting protein 2 |
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| Clone: | Nick-1 |
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| Host: | Rat |
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| Isotype: | IgG2a |
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| Immunogen: | Recombinant human RIP2 (receptor-interacting protein 2) (aa 1-322). |
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| UniProt ID: | O43353 |
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| Source: | Purified from hybridoma tissue culture supernatant. |
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| Species reactivity: | Human
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| Applications: | WB
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Use/Stability: | Stable for at least 1 year after receipt when stored as recommended. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Detection of endogenous human RIP2 in different human cell lines by the MAb to RIP2 (Nick-1) (Prod. No.
ALX-804-139).
Method: Total cell extracts (50µg) from Jurkat (lane1), THP-1 (lane 2) and HT1080 (lane 3) cell ljnes were run on a SDS-gel, and revealed with MAb to RIP2 (Nick-1) (1:1’000 in 5% milk powder) for 1 hour at rooom temperature followed by incubation with HRP-coupled anti-rat secondary antibody (1:4’000)."
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Product Literature References
BNN-20, a synthetic microneurotrophin, strongly protectsdopaminergic neurons in the "weaver" mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor: K. Botsakis, et al.; Neuropharmacology
121, 140 (2017),
Abstract;
Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity: C. Lu, et al.; J. Biol. Chem.
280, 16278 (2005),
Abstract;
Full Text
Participation of Rip2 in LPS signaling is independent of its kinase activity: C. Lu, et al.; J. Biol. Chem.
280, 16278 (2005),
Abstract;
Full Text
PIDD mediates NF-kB activation in Response to DNA damage: Janssens, et al.; Cell
123, 1079 (2005),
Abstract;
