Product Details
| Alternative Name: | p88, IP90 |
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| Clone: | AF18 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Focus human hepatoma cell line. |
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| UniProt ID: | P27824 |
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| Species reactivity: | Human, Mouse
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| Applications: | ICC, IP, WB
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| Recommended Dilutions/Conditions: | Immunocytochemistry (1:500)
Immunoprecipitation, Western Blot (1:4,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~90kDa by Western blot. |
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| Formulation: | Liquid. Ascites diluted in PBS containing 0.05% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Calnexin, also referred to as IP90 or p88, is a ~88kDa chaperone protein found in the endoplastmic reticulum. It binds with partially folded immunoglobulin proteins and retains them in the endoplastmic reticulum until they are completely folded. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
VAP (VAMP-Associated Proteins) as Receptors that couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis: W.L. Ernst, et al.; J. Biol. Chem.
291, 5206 (2016),
Application(s): Cell culture,
Abstract;
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Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis: H. Zhang, et al.; J. Biol. Chem.
281, 11312 (2006),
Abstract;
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The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma: K.T. Chin, et al.; Nucl. Acids Res.
33, 1859 (2005),
Abstract;
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The stop transfer sequence of the human UDP-glucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms: L. Barre, et al.; Febs J.
272, 1063 (2005),
Abstract;
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An LQT mutant minK alters KvLQT1 trafficking: A. Krumerman, et al.; Am. J. Physiol. Cell Physiol.
286, C1453 (2004),
Abstract;
Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER: R. Khanna, et al.; J. Cell Sci.
117, 2897 (2004),
Abstract;
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Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex: J. Enninga, et al.; Mol. Cell. Biol.
23, 7271 (2003),
Abstract;
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c-erbB-3: a nuclear protein in mammary epithelial cells: M. Offterdinger, et al.; J. Cell Biol.
157, 929 (2002),
Abstract;
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Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator: H. Zhang, et al.; J. Biol. Chem.
277, 28948 (2002),
Abstract;
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FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction: B.N. Desai, et al.; PNAS
99, 4319 (2002),
Abstract;
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Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm: P.P. Li, et al.; PNAS
99, 1353 (2002),
Abstract;
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The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene: K. Galvin, et al.; PNAS
89, 8452 (1992),
Abstract;
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