Product Details
| Alternative Name: | αV integrin, Vitronectin receptor α subunit |
| |
| Clone: | L230 |
| |
| Host: | Mouse |
| |
| Isotype: | IgG1 |
| |
| Immunogen: | Human endothelial cells. |
| |
| UniProt ID: | P06756 |
| |
| Species reactivity: | Human
|
| |
| Specificity: | Recognizes heterodimers αVβ3, αVβ1, αVβ5 and αVβ6. |
| |
| Crossreactivity: | Does not cross-react with other species. |
| |
| Applications: | ELISA, Flow Cytometry, IF, IHC, IP, FUNC
|
| |
| Application Notes: | Functional Application: αV integrin blocking |
| |
| Purity Detail: | Protein A-affinity purified. |
| |
| Formulation: | Liquid. In PBS containing 0.05% sodium azide. |
| |
| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
| |
| Shipping: | Blue Ice |
| |
| Short Term Storage: | +4°C |
| |
| Long Term Storage: | -20°C |
| |
| Scientific Background: | CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3 is also highly expressed in osteoclasts being important for bone resorption. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
Three-Dimensional Porous Scaffolds Derived from Bovine Cancellous Bone Matrix Promote Osteoinduction, Osteoconduction, and Osteogenesis: A. Malagón-Escandón, et al.; Polymers (Basel)
13, 4390 (2021),
Abstract;
Polarized Entry of Human Parechoviruses in the Airway Epithelium: E. Karelehto, et al.; Front. Cell. Infect. Microbiol.
8, 294 (2018),
Abstract;
Full Text
A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix: L.M. Owen, et al.; Mol. Biol. Cell
28, 1959 (2017),
Abstract;
Full Text
Mammary-derived growth inhibitor (MDGI) interacts with integrin alpha-subunits and suppresses integrin activity and invasion: J. Nevo, et al.; Oncogene
29, 6452 (2010),
Abstract;
PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells: S. Tuomi, et al.; Sci. Signal.
2, ra32 (2009),
Abstract;
Full Text
Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9: C.H. Williams, et al.; J. Virol.
78, 6967 (2004),
Abstract;
Full Text
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading: P. Di Stefano, et al.; Mol. Biol. Cell
15, 787 (2004),
Abstract;
Full Text
Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines: L. Moro, et al.; J. Biol. Chem.
277, 9405 (2002),
Abstract;
Full Text
A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells: B.R. Schwartz, et al.; J. Immunol.
162, 4842 (1999),
Abstract;
Full Text
Role of the Integrin avp6 in Cell Attachment to Fibronect: A. Weinacker, et al.; J. Biol. Chem.
269, 6940 (1994),
Application(s): IP using human SK-Mel-19, MG-63, HeLa, and FG cell lysates; alphav integrin blocking using human 293, MG-63, FG and SW480beta6 cells,
Abstract;
Full Text
