Selective ligand for Toll-like receptor 7 (TLR7) via IFN. Activates natural killer cells and primes cytolytic precursor cells for activation by IL-2.
Product Details
| Alternative Name: | 7-Allyl-8-oxoguanosine, RWJ 21757 |
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| Formula: | C13H17N5O6 |
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| MW: | 339.3 |
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| CAS: | 121288-39-9 |
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| Purity: | ≥97% (HPLC (UV)) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (30mg/ml), water (10mg/ml), water:acetonitrile (1:1) (20mg/ml) or water:methanol (1:1) (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases: A. Kanno, et al.; Nat. Commun.
6, 6119 (2015),
Application(s): Cell Culture,
Abstract;
Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN: I.B. Bekeredjian-Ding, et al.; J. Immunol.
174, 4043 (2005),
Abstract;
Full Text
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7: J. Lee, et al.; PNAS
100, 6646 (2003),
Abstract;
Full Text
The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines: B.L. Pope, et al.; Cell. Immunol.
162, 333 (1995),
Abstract;
Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle: M.G. Goodman, et al.; Blood
84, 3457 (1994),
Abstract;
Full Text
Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression: U. Schindler and V.R. Baichwal; Mol. Cell. Biol.
14, 5820 (1994),
Abstract;
Full Text
Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2: B.L. Pope, et al.; J. Immunol.
151, 3007 (1993),
Abstract;
