Cytotoxic in various cell lines. Induces apoptosis via elevation of peroxide and superoxide radical levels. Affects gap-junctional intercellular communication by mediation of tyrosine phosphorylation.Inhibitor of indoleamine 2,3-dioxygenase (IDO) with an IC50 of ~1µM.
Product Details
| Alternative Name: | Vitamin K3, 2-Methyl-1,4-naphthoquinone |
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| Formula: | C11H8O2 |
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| MW: | 172.2 |
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| CAS: | 58-27-5 |
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| MI: | 14: 5831 |
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| RTECS: | QL9100000 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white to yellow crystalline solid. |
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| Solubility: | Soluble in 96% ethanol (16mg/ml) or DMSO (1mg/ml); almost insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The Role of HSP40 Conserved Motifs in the Response to Cytotoxic Stress: S.J. Sojourner, et al.; J. Nat. Sci.
4, e500 (2018),
Abstract;
Full Text
Flow cytometric evaluation of sperm superoxide anion production in rats with experimental varicocele: A. Jafari, et al.; Urology
75, 217 (2010),
Abstract;
Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors: S. Kumar, et al.; J. Med. Chem.
51, 1706 (2008),
Abstract;
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells: D.N. Criddle, et al.; J. Biol. Chem.
281, 40485 (2006),
Abstract;
Full Text
Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy: J. Mauzeroll, et al.; PNAS
101, 17582 (2004),
Abstract;
Full Text
2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade: L.O. Klotz, et al.; Cancer Res.
62, 4922 (2002),
Abstract;
Full Text
Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines: H. Okayasu, et al.; Anticancer Res.
21, 2387 (2001),
Abstract;
Apoptosis-inducing activity of vitamin C and vitamin K: H. Sakagami, et al.; Cell Mol. Biol.
46, 129 (2000),
Abstract;
Cytotoxic effect through fas/APO-1 expression due to vitamin K in human glioma cells: L.K. Sun, et al.; J. Neurooncol.
47, 31 (2000),
Abstract;
Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase: F.Y. Wu and T.P.; Eur. J. Cancer
35, 1388 (1999),
Abstract;
