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MnTBAP chloride

SOD mimetic. Peroxynitrite scavenger.



ALX-430-069-M010	10 mg	46.00 USD

ALX-430-069-M050	50 mg	123.00 USD
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Replaces Prod. #: BML-FR107

Cell permeable superoxide dismutase (SOD) mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Inhibits neuronal apoptosis.

Product Details

Formula:	C₄₈H₂₈MnN₄O₈Cl

MW:	879.2

Purity:	≥95% (TLC)

Appearance:	Black crystalline powder.

Solubility:	Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.

Shipping:	Ambient Temperature

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 2 years after receipt when stored at -20°C.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Ao Overproduction of nitric oxide by endothelial cells and macrophages contributes to mitochondrial oxidative stress in adrenocortical cells and adrenal insufficiency during endotoxemia: C.N. Wang, et al.; Free Radic. Biol. Med. 83, 31 (2015), Application(s): Injection, Abstract;

Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis: H. Dussmann, et al.; J. Biol. Chem. 278, 12645 (2003), Abstract; Full Text

Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen.: S. Kotamraju, et al.; J. Biol. Chem. 275, 33585 (2000), Abstract; Full Text

Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem. 275, 13613 (2000), Abstract; Full Text

Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation: P. Ghafourifar, et al.; J. Biol. Chem. 274, 31185 (1999), Abstract; Full Text

Reactive oxygen species regulate activation-induced T cell apoptosis:: D.A. Hildeman, et al.; Immunity 10, 735 (1999), Abstract;

Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger: C. Szabó, et al.; FEBS Lett. 381, 82 (1996), Abstract;

A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro: B.J. Day, et al.; J. Pharm. Exp. Ther. 275, 1227 (1995), Abstract;

Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994), Abstract; Full Text

General Literature References

Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic: M. Patel; J. Neurochem. 71, 1068 (1998), Abstract;

The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock: B. Zingarelli, et al.; Br. J. Pharmacol. 120, 259 (1997), Abstract;