Immunologically inactive. Does not bind to immunophilin. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. BML-PE160) in mouse skin in vivo. Potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Potent and selective antagonist of formyl peptide receptor. Inhibits formyl peptide-induced superoxide formation.
Product Details
| Alternative Name: | Csh-cyclosporin, 5-(N-Methyl-D-valine)-cyclosporin A |
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| Formula: | C62H111N11O12 |
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| MW: | 1202.6 |
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| Source: | Isolated from Tolypocladium inflatum. |
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| CAS: | 83602-39-5 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA: B. Pantic, et al.; Nat. Commun.
12, 6997 (2021),
Abstract;
The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis: I. Snapkov, et al.; BMC Cancer
16, 490 (2016),
Application(s): Inhibition of FPR1 signaling and Ca2+ mobilization,
Abstract;
Full Text
Antimicrobial peptide scolopendrasin VII, derived from the centipede Scolopendra subspinipes mutilans, stimulates macrophage chemotaxis via formyl peptide receptor 1: Y. J. Park, et al.; BMB Rep.
48, 479 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S: G.Y. Cheung, et al. ; Sci. Rep.
5, 18023 (2015),
Application(s): Cell culture,
Abstract;
Full Text
Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor: A.L. Stenfeldt, et al.; Inflammation
30, 224 (2007),
Abstract;
Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine: A. de Paulis, et al.; J. Allergy Clin. Immunol.
98, 152 (1996),
Abstract;
Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E: K. Wenzel-Seifert & R. Seifert; J. Immunol.
150, 4591 (1993),
Abstract;
Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation: K. Wenzel-Seifert, et al.; J. Immunol.
147, 1940 (1991),
Abstract;
The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC
150, 545 (1988),
Abstract;
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