Antibiotic. Inhibits prokaryote protein synthesis. Binds to the S12 protein of the 30S ribosomal subunit. Effective against Gram-negative and Gram-positive bacteria. Mutation in rpsL (the gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Inactivated by aminoglycoside phosphotransferase.
Product Details
| Formula: | C42H84N14O36S3 |
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| MW: | 1457.4 |
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| Source: | Isolated from Streptomyces sp. |
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| CAS: | 3810-74-0 |
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| MI: | 14: 8826 |
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| RTECS: | WK4990000 |
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| Appearance: | White to off-white powder. |
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| Activity: | Potency is >650 μg/mg (on dry basis). |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Streptomycin revisited: molecular action in the microbial cell: J.D. Kornder; Med. Hypotheses
58, 34 (2002),
Abstract;
Mechanism of inhibition of ribosomes by streptomycin: J. Modolell & B.D. Davis; Nature
224, 345 (1969),
Abstract;
