Nucleic acid binding ligand. Binds to A-T-rich regions of the minor groove of DNA.
Product Details
| Alternative Name: | 4-([((Aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-3-carboxamide |
| |
| Formula: | C18H26N10O3 . 2HCl |
| |
| MW: | 430.5 . 73.0 |
| |
| Source: | Isolated from Streptomyces netropsis. |
| |
| CAS: | 18133-22-7 |
| |
| RTECS: | DW2973000 |
| |
| Purity: | ≥90% (HPLC) |
| |
| Appearance: | Faint yellow powder. |
| |
| Solubility: | Soluble in alcohols or water. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Handling: | Protect from light. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Recent developments in sequence selective minor groove DNA effectors: B.S. Reddy, et al.; Curr. Med. Chem.
8, 475 (2001), (Review),
Abstract;
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2: K. Bielawski, et al.; Acta Biochim. Pol.
47, 855 (2000),
Abstract;
Sequence and structural selectivity of nucleic acid binding ligands: J. Ren & J.B. Chaires; Biochemistry
38, 16067 (1999),
Abstract;
Efficient Total Syntheses of the Oligopeptide Antibiotics Netropsin and Distamycin: J.W. Lown et al.; J. Org. Chem. 50, 3774 (1985),
Netropsin, a New Antibiotic Produced by a Streptomyces: A.C. Finlay et al.; J. Am. Chem. Soc. 73, 341 (1951),
