Antibiotic with high activity. Inhibits growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA. Penetrates cells that have been permeabilized by virus infection, hence it can act as an effective antiviral agent.
Product Details
| Alternative Name: | O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine |
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| Formula: | C20H37N3O13 |
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| MW: | 527.5 |
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| Source: | Isolated from Streptomyces hygroscopicus. |
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| CAS: | 31282-04-9 |
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| MI: | 14: 4852 |
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| RTECS: | WK2130000 |
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| Quantity: | 1MU (1 million units); potency ≥385 U/mg solution. |
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| Concentration: | ≥450’000U/ml |
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| Purity: | ≥80% (HPLC) |
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| Appearance: | Dark brown solution. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Technical Info/Product Notes: | Microbiological assay: 350'000-500'000U/ml. Solution has to be sterile-filtered before use. For ready-to-use sterile Hygromycin B solutions please refer to Prod. No. ALX-380-306 and ALX-380-309. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Hygromycin B inhibition of protein synthesis and ribosome biogenesis in Escherichia coli: S. M. McGaha & W. S. Champney; Antimicrob. Agents Chemother.
51, 591 (2007),
Abstract;
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes: M. C. Ganoza & M. C. Kiel; Antimicrob. Agents Chemother.
45, 2813 (2001),
Abstract;
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit:: D.E. Brodersen, et al.; Cell
103, 1143 (2000),
Abstract;
Induction of p53-independent apoptosis by hygromycin B: suppression by Bcl-2 and adenovirus E1B 19-kDa protein: G. Chen, et al.; Exp. Cell Res.
221, 55 (1995),
Abstract;
Antiviral effects of hygromycin B, a translation inhibitor nonpermeant to uninfected cells: J. C. Lacal & L. Carrasco; Antimicrob. Agents Chemother.
24, 273 (1983),
Abstract;
The Isolation of a Second Antibiotic from Streptomyces hygroscopicus: R. L. Mann & W. W. Bromer; J. Am. Chem. Soc. 80, 2714 (1958),
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