Neurotoxin that acts as an inhibitor of the M phase of the mammalian cell cycle. Inhibits Ca2+-activated K+ channels. Decreases GABA levels in CNS.
Product Details
| Formula: | C27H33N3O7 |
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| MW: | 511.6 |
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| Source: | Isolated from Penicillium verruculosum. |
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| CAS: | 12771-72-1 |
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| RTECS: | JH4920000 |
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| Purity: | ≥95% (HPLC, TLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in ethyl acetate, DMSO, 100% ethanol or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres.: I. Kosalec, et al.; Acta Pharm.
55, 357 (2005),
Abstract;
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico- chemical properties and structures: C.B. Cui, et al.; J. Antibiot. (Tokyo)
49, 534 (1996),
Abstract;
Tremorgenic indole alkaloids potently inhibit smooth muscle high- conductance calcium-activated potassium channels: H.H. Knaus, et al.; Biochemistry
33, 5819 (1994),
Abstract;
