Minor component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1F0), preventing phosphoryl group transfer. Induces apoptosis.
Product Details
| Alternative Name: | 28-Oxooligomycin A |
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| Formula: | C45H72O12 |
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| MW: | 805.1 |
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| Source: | Isolated from Streptomyces sp. MST-AS5339. |
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| CAS: | 11050-94-5 |
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| MI: | 14: 6833 |
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| RTECS: | RK3330000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy
50, 55 (2004),
Abstract;
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene
21, 8149 (2000),
Abstract;
Full Text
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ.
7, 338 (2000),
Abstract;
Full Text
Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Egr.
2, 31 (1960),
Abstract;
