Cell permeable inhibitor of uncoupling protein 2 (UCP2). Increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Induces apoptosis. Protein cross-linking agent. Anti-inflammatory and anti-angiogenic.
Product Details
| Alternative Name: | (+)-Genipin, Methyl (1S,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate |
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| Formula: | C11H14O5 |
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| MW: | 226.2 |
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| Source: | Isolated from Gardenia jasminoides Ellis. |
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| CAS: | 6902-77-8 |
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| RTECS: | GY5828000 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in DMSO (50mg/ml), dimethyl formamide (25mg/ml), 100% ethanol (5mg/ml), methanol or ethyl acetate; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
In situ formation of silk-gelatin hybrid hydrogels for affinity-based growth factor sequestration and release: J.C. Bragg, et al.; RSC Advances 6, 114353 (2016),
Tissue engineering of ureteral grafts: Preparation of biocompatible crosslinked ureteral scaffolds of porcine origin: H. Koch, et al.; Front. Bioeng. Biotechnol.
3, 89 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity: L.E. Parton, et al.; Nature
449, 228 (2007),
Abstract;
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets: C.Y Zhang, et al.; Cell Metab.
3, 417 (2006),
Abstract;
Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway: B.C. Kim, et al.; Biochem. Pharmacol.
70, 1398 (2005),
Abstract;
