Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC50=16.8µM). Isomeric with honokiol (Prod. No. ALX-350-350).
Product Details
| Alternative Name: | 5,5’-Diallyl-2,2’-biphenyldiol |
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| Formula: | C18H18O2 |
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| MW: | 266.3 |
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| Source: | Isolated from Magnolia officinalis. |
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| CAS: | 528-43-8 |
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| MI: | 14: 5697 |
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| RTECS: | DV5105500 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to light yellow powder. |
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| Solubility: | Soluble in DMSO, 100% ethanol or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull.
30, 2201 (2007),
Abstract;
Full Text
Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells: T. Ikai, et al.; Biol. Pharm. Bull.
29, 2498 (2006),
Abstract;
Full Text
Inhibitory effect of magnolol on tumour metastasis in mice: K. Ikeda, et al.; Phytother. Res.
17, 933 (2003),
Abstract;
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med.
66, 469 (2000),
Abstract;
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod.
61, 135 (1998),
Abstract;
Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med.
49, 103 (1983),
Abstract;
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