Replaces Prod. #: BML-AP304
Immunosuppressive agent with anti-inflammatory and antitumor properties. More effective in preventing T cell proliferation and interferon-γ production than FK506 (Prod. No. ALX-380-008). Induces apoptosis in T cells by activating DEVD cleaving caspases. Blocks TNF-α mediated induction of c-IAP1 and c-IAP2 and NF-κB activation. Inhibits induction of MMP-3, MMP-13, and ADAMTS-4 in cell culture.
Product Details
| Alternative Name: | PG490 |
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| Formula: | C20H24O6 |
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| MW: | 360.4 |
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| Source: | Isolated from Tripterygium wilfordii. |
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| CAS: | 38748-32-2 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (1mg/ml) (1h at 37°C). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation: T. Sutani, et al.; Nat. Commun.
6, 7815 (2015),
Application(s): Inhibitors ,
Abstract;
Full Text
Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats: L. Liu, et al.; Toxicology
271, 57 (2010),
Abstract;
Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells: B.Z. Carter, et al.; Blood
108, 630 (2006),
Abstract;
Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death: S.D. Westerheide, et al.; J. Biol. Chem.
281, 9616 (2006),
Abstract;
Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes: A. Liacini et al.; Biochem. Biophys. Res. Commun.
327, 320 (2005),
Abstract;
Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells: Y. Miyata, et al.; BBRC
336, 1081 (2005),
Abstract;
Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.: D. Qiu & P.N. Kao; Drugs R. D.
4, 1 (2003), (Review),
Abstract;
Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T- cells and NF-kappaB transcriptional activation: D. Qiu, et al.; J. Biol. Chem.
274, 13443 (1999),
Abstract;
Full Text
PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells: K.Y. Lee, et al.; J. Biol. Chem.
274, 13451 (1999),
Abstract;
Full Text
Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506: M.A. Chan, et al.; Phytother. Res.
13, 464 (1999),
Abstract;
Triptolide induces apoptotic death of T lymphocyte: Y. Yang, et al.; Immunopharmacology
40, 139 (1998),
Abstract;
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