Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats.
Product Details
| Alternative Name: | L-Sulforaphane, (-)-1-Isothiocyanato-(4R)-(methylsulfinyl)butane |
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| Formula: | C6H11NOS2 |
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| MW: | 177.3 |
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| Source: | Chiral natural product isolated from broccoli. |
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| CAS: | 142825-10-3 |
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| MI: | 14: 8962 |
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| Purity: | ≥98% (UHPLC) |
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| Appearance: | Slightly yellowish liquid. **Please note this product can be very difficult to see and may present as an almost invisible film. |
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| Solubility: | Soluble in methanol, 100% ethanol, DMSO or ethyl acetate. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
GSH Levels Serve As a Biological Redox Switch Regulating Sulforaphane-Induced Cell Fate in Human Lens Cells: T.P.N. Huynh, et al.; Invest. Ophthalmol. Vis. Sci.
62, 1167 (2021),
Abstract;
Phytochemicals Resveratrol and Sulforaphane as Potential Agents for Enhancing the Anti-Tumor Activities of Conventional Cancer Therapies: B.M. Kaminski, et al.; Curr. Pharm. Biotechnol.
13, 137 (2012),
Abstract;
Protective effect of sulforaphane against oxidative stress: Recent advances: C.E. Guerrero-Beltran, et al.; Exp. Toxicol. Pathol.
64, 503 (2012),
Abstract;
Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage: P. Bergstrom, et al.; Neuropharmacology
60, 343 (2011),
Abstract;
Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53: E. Rudolf & M. Cervinka; Toxicol. In Vitro
25, 1302 (2011),
Abstract;
The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer: A.F. Abdull Razis, et al.; Int. J. Cancer
128, 2775 (2011),
Abstract;
Sulforaphane induces DNA single strand breaks in cultured human cells: P. Sestili, et al.; Mutat. Res.
689, 65 (2010),
Abstract;
Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut
58, 949 (2009),
Abstract;
Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex: M.L. Kerns, et al.; PNAS
104, 14460 (2007),
Abstract;
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak ,et al.; Cancer Res.
64, 5767 (2004),
Abstract;
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Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage: X. Gao & P. Talalay; PNAS
101, 10446 (2004),
Abstract;
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors: J.W. Fahey, et al.; PNAS
99, 7610 (2002),
Abstract;
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Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS
91, 3147 (1994),
Abstract;
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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS
89, 2399 (1992),
Abstract;
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