Antibiotic. Inhibitor of NF-κB activation by preventing the phosphorylation of IκB protein and thereby interrupts the signalling pathway. Strongly inhibits the expression of several NF-κB dependent pro-inflammatory genes.
Product Details
| Formula: | C11H14O4 |
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| MW: | 210.2 |
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| Source: | Isolated from Lentinus crinitus. |
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| CAS: | 31298-54-1 |
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| Purity: | ≥95% (HPLC, MS) |
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| Appearance: | Yellow oil. |
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| Solubility: | Soluble in DMSO, 100% ethanol or methanol. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Keep cool and dry. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus: R.E. Watkinson, et al.; PLoS Pathog.
11, e1005253 (2015),
Application(s): NF-κB inhibitor,
Abstract;
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Tumor necrosis factor (TNF)-alpha upregulates progesterone receptor-A by activating the NF-kappaB signaling pathway in human decidua after labor onset: Z.Y. Jiang, et al.; Placenta
33, 1 (2012),
Abstract;
Activation of cytokine expression occurs through the TNFalpha/NF-kappaB-mediated pathway in birnavirus-infected cells: W.L. Wang, et al.; Fish Shellfish Immunol.
31, 10 (2011),
Abstract;
Regulation of glycosyltransferases and Lewis antigens expression by IL-1beta and IL-6 in human gastric cancer cells: M. Padro, et al.; Glycoconj. J.
28, 99 (2011),
Abstract;
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells: G. Erkel, et al.; Int. Immunopharmacol.
7, 612 (2007),
Abstract;
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter: M. Ramanathan, et al.; Mol. Biol. Cell
18, 14 (2007),
Abstract;
Full Text
Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent: J.B. Shotwell, et al.; Bioorg. Med. Chem. Lett.
12, 3463 (2002),
Abstract;
Molecular design and biological activities of NF-kappaB inhibitors: K. Umezawa & C. Chaicharoenpong; Mol. Cells
14, 163 (2002),
Abstract;
Naturally occurring and synthetic inhibitors of NF-kappaB functions: K. Umezawa, et al.; Anticancer Drug Des.
15, 239 (2000),
Abstract;
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways: H. Kleinert, et al.; Br. J. Pharmacol.
125, 193 (1998),
Abstract;
Inhibition of NF-kappa B activation by panepoxydone: G. Erkel, et al.; BBRC
226, 214 (1996),
Abstract;
