Activates PPARα and the phospholipase C (PLC) signalling pathway. Stimulates peroxisomal fatty acyl-CoA oxidase activity. These effects can be blocked by staurosporine (Prod. No. ALX-380-014). Exhibits significant cytotoxic activities against numerous tumor cell lines. Binds tubulin. Inhibits angiogenesis. Reduces HIF-1α protein levels. Induces apoptosis. Antifungal.
Product Details
| Alternative Name: | Pseudolarix acid B, PLAB, PAB |
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| Formula: | C23H28O8 |
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| MW: | 432.5 |
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| Source: | Isolated from Pseudolarix kaempferi. |
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| CAS: | 82508-31-4 |
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| RTECS: | KJ4620000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Off-white to light brown solid. |
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| Solubility: | Soluble in DMSO, 100% ethanol or chloroform. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Structural modification of an angiogenesis inhibitor discovered from traditional chinese medicine and a structure-activity relationship study: S.P. Yang, et al.; J. Med. Chem.
51, 77 (2008),
Abstract;
Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene: J.K. Ko, et al.; Eur. J. Pharmacol.
559, 1 (2007),
Abstract;
Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death: X. Gong, et al.; Exp. Mol. Med.
38, 428 (2006),
Abstract;
Full Text
Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin: Y.G. Tong, et al.; Mol. Pharmacol.
69, 1226 (2006),
Abstract;
Studies on anti-tumour activities of pseudolaric acid-B (PLAB) and its mechanism of action: B. Liu, et al.; J. Asian Nat. Prod. Res.
8, 241 (2006),
Abstract;
Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis: K.S. Li, et al.; World J. Gastroenterol.
11, 7555 (2005),
Abstract;
Full Text
Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells: X.F. Gong, et al.; Arch. Pharm. Res.
28, 68 (2005),
Abstract;
Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo: V.K. Wong, et al.; Clin. Cancer Res.
11, 6002 (2005),
Abstract;
Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation: M.H. Li, et al.; Clin. Cancer Res.
10, 8266 (2004),
Abstract;
Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor-mediated anti-apoptotic effect: W.F. Tan, et al.; Eur. J. Pharmacol.
499, 219 (2004),
Abstract;
Antifungal diterpenoids of Pseudolarix kaempferi, and their structure-activity relationship study: S.P. Yang, et al.; Bioorg. Med. Chem.
11, 4577 (2003),
Abstract;
Five new diterpenoids from Pseudolarix kaempferi: S.P. Yang, et al.; J. Nat. Prod.
65, 1041 (2002),
Abstract;
Pseudolaric acid analogs as a new class of peroxisome proliferator-activated receptor agonists: M.S. Jardat, et al.; Planta Med.
68, 667 (2002),
Abstract;
Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferi: E. Li, et al.; J. Nat. Prod.
58, 57 (1995),
Abstract;
The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives: D.J. Pan, et al.; Planta Med.
56, 383 (1990),
Abstract;
Pseudolaric Acids from Pseudolarix kaempferi: B.N. Zhou, et al.; Planta Med.
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Abstract;
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