Replaces Prod. #: BML-EI147
Tyrosine protein kinase inhibitor. Inhibits phosphorylation of EGFR kinase. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits topoisomerase II activity in vivo. Produces cell cycle arrest and apoptosis. Potent inhibitor of α-glucosidase, IC50 = 50nM.Direct inhibitor of insulin-induced glucose uptake in adipocytes (IC50=20µM).
Product Details
Alternative Name: | 4',5,7-Trihydroxyisoflavone |
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Formula: | C15H10O5 |
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MW: | 270.2 |
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Source: | Synthetic. |
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CAS: | 446-72-0 |
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MI: | 14: 4391 |
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RTECS: | NR2392000 |
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Purity: | ≥98% (HPLC) |
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Appearance: | Creamy off-white solid. |
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Solubility: | Soluble in DMSO (30mg/ml), 100% ethanol (4mg/ml) or dilute aqueous base; insoluble in water. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Handling: | Protect from light. |
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Technical Info/Product Notes: | Replacement for ADI-HPK-103 |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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GM101 in Combination with Histone Deacetylase Inhibitor Enhances Anti-Tumor Effects in Desmoplastic Microenvironment: H.G. Chang, et al.; Cells
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Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation: A. Breit, et al.; Mol. Endocrinol.
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Phytoestrogens and lipoproteins in women: C.N. Bairey Merz, et al.; J. Clin. Endocrinol. Metab.
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Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes: M. Bazuine, et al.; BBRC
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Genistein affects testosterone secretion by Leydig cells in roosters (Gallus gallus domesticus): M. Opalka, et al.; Reprod. Biol.
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Genistein, a soy isoflavone, is a potent alpha-glucosidase inhibitor: D.S. Lee & S.H. Lee; FEBS Lett.
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The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release: P.J. Lane et al.; J. Immunol.
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Effect of genistein, a tyrosine kinase inhibitor, on U46619-induced phosphoinositide phosphorylation in human platelets: D.C. Gaudette & J. B. Holub; Biochem. Biophys. Res. Commun.
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Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets: H. Salari, et al.; FEBS Lett.
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Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity: C. Linassier et al.; Biochem. Pharmacol.
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Abstract;
T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation: T. Mustelin et al.; Science
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Abstract;
Effects of the tyrosine-kinase inhibitor genistein on DNA synthesis and phospholipid-derived second messenger generation in mouse 10T1/2 fibroblasts and rat liver T51B cells: N.M. Dean et al.; Biochem. Biophys. Res. Commun.
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Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem.
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Full Text