PARP-2 specific inhibitor with 60-fold selectivity for PARP-2 (IC50=0.15 ± 0.04μM) over PARP-1 (IC50=9.0 ± 0.7μM). Can be used for further characterization of PARP-2 in pathophysiological conditions.
Product Details
| Alternative Name: | 5-Benzoyloxy-3,4-dihydroisoquinolin-1(2H)-one |
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| Formula: | C16H11NO3 |
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| MW: | 265.3 |
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| CAS: | 370872-09-6 |
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| Purity: | ≥95% (HPLC) |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Not stable in basic conditions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage: F. Moroni, et al.; Br. J. Pharmacol.
157, 854 (2009),
Abstract;
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives: R. Pellicciari, et al.; ChemMedChem
3, 914 (2008),
Abstract;
