Inhibitor of protein farnesylation in a cell free assay. Inhibits incorporation of tritiated mevalonate into proteins in whole cells. Mycotoxin with anti-bacterial, potassium uptake inhibitory and possibly carcinogenic activities. Known contaminant of spoiled apples.
Product Details
| Alternative Name: | 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one, Clairformin, Clavacin, Clavatin, Claviformin, Leucopin, Mycoin C3, Mycosin, Penicidin, Terinin |
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| Formula: | C7H6O4 |
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| MW: | 154.1 |
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| Source: | Isolated from Penicillium expansum. |
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| CAS: | 149-29-1 |
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| MI: | 14: 7053 |
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| RTECS: | LV2625000 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | White crystalline solid. |
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| Solubility: | Soluble in DMSO, methanol, ethanol or water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Application(s): Incubated into Caco-2 cells,
Abstract;
Full Text
Hplc detection of patulin in apple juice with GC/MS confirmation of patulin identity: J.A. Roach, et al.; Adv. Exp. Med. Biol.
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Abstract;
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Abstract;
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318, 88 (1993),
Abstract;
Chronology of patulin-induced alterations in membrane function of cultured renal cells, LLC-PK: R.T. Riley, et al.; Toxicol. Appl. Pharmacol.
102, 128 (1990),
Abstract;
Patulin: IARC Monographs
10, 205 (1976),
Full Text
Effects of various lactones and related compounds on cation transfer in incubated cold-stored human erythrocytes: J.B. Kahn, Jr.; J. Pharmacol. Exp. Ther.
121, 234 (1957),
Abstract;
Patulin in the common cold - Collaborative research on a derivative of Penicillium patulum bainier - II. Biochemistry and Chemistry: M. Birkinshaw, et al.; Lancet
245, 625 (1943),
Abstract;
