Replaces Prod. #: BML-G400
Inhibits endogenous poly-ADP-ribosyltransferases often present in membrane preparations with minimal effect of bacterial toxin mediated ADP-ribosylation. Inhibits nitric oxide-induced apoptosis but not differentiation in HL-60 cells. Protects cells from oxygen radical and nitric oxide toxicity. Inhibits stress-induced apoptosis.
Product Details
| Alternative Name: | 3-AB |
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| Formula: | C7H8N2O |
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| MW: | 136.2 |
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| CAS: | 3544-24-9 |
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| RTECS: | CU8992000 |
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| Purity: | ≥97% (GC) |
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| Appearance: | White to tan powder. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors
9, 173 (2016),
Application(s): Cell culture,
Abstract;
Full Text
Genistein induces apoptotic cell death associated with inhibition of the NF-κB pathway in adult T-cell leukemia cells: M. Yamasaki, et al.; Cell. Biol. Int.
37, 742 (2013),
Abstract;
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell
32, 57 (2008),
Abstract;
Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents: A. Pogrebniak, et al.; Eur. J. Med. Res.
11, 313 (2006),
Abstract;
Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells: M.L. Kuo, et al.; BBRC
219, 502 (1996),
Abstract;
3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion: W. Malorni, et al.; BBRC
207, 715 (1995),
Abstract;
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells: B. Heller, et al.; J. Biol. Chem.
270, 11176 (1995),
Abstract;
Cell death protection by 3-aminobenzamide and other poly(ADP- ribose)polymerase inhibitors: different effects on human natural killer and lymphokine activated killer cell activities: D. Monti, et al.; BBRC
199, 525 (1994),
Abstract;
Cell death protection by 3-aminobenzamide: impairment of cytoskeleton function in human NK cell-mediated killing: W. Malorni, et al.; BBRC
199, 1250 (1994),
Abstract;
Possible involvement of poly(ADP-ribosyl) polymerase in triggering stress-induced apoptosis: C. Nosseri, et al.; Exp. Cell Res.
212, 367 (1994),
Abstract;
Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis: K.R. Kozak and I.A. Ross; BBRC
179, 1225 (1991),
Abstract;
ADP-Ribose Transfer Reactions, Mechanisms and Biological Significance (M.K. Jacobsen & E.L. Jacobsen, eds.): C.J. Skidmore, et al.; Springer Verlag, New York 109 (1989),
