Potent, selective and reversible inhibitor of human cathepsin L (IC50=1.9nM). Inhibits release of Ca2+ and hydroxyproline from bone in vitro.
Product Details
| Alternative Name: | N-(1Naphthalenylsulfonyl)- IW-CHO |
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| Formula: | C27H29N3O4S |
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| MW: | 491.6 |
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| CAS: | 161709-56-4 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO or ethyl acetate (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells: D. Chauss, et al.; Nat. Immunol.
23, 62 (2022),
Abstract;
Cathepsin L-containing exosomes from α-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor: T. Jiang, et al.; NPJ Parkinsons Dis.
8, 127 (2022),
Abstract;
The protease cathepsin L regulates Th17 cell differentiation: L. Hou, et al.; J. Autoimmun.
65, 56 (2015),
Application(s): Cell Culture,
Abstract;
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice: T. Wartmann, et al.; Gastroenterology
138, 726 (2010),
Abstract;
Full Text
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption: T. Yasuma, et al.; J. Med. Chem.
41, 4301 (1998),
Abstract;
