Replaces Prod. #: BML-PI118
Competitive and reversible inhibitor of serine and cysteine proteinases like calpain, porcine kallikrein, trypsin, plasmin, papain and cathepsin B. Does not inhibit chymotrypsin and thrombin. Also known to inhibit activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors.
Product Details
| Alternative Name: | Acetyl-L-leucyl-L-leucyl-L-argininal . hemisulfate |
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| Formula: | C20H38N6O4 . 0.5 H2SO4 |
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| MW: | 426.6 . 49.0 |
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| Source: | Synthetic. |
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| CAS: | 103476-89-7 |
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| MI: | 14: 5456 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water, methanol or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and moisture. |
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| Technical Info/Product Notes: | Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined using three main peaks. Majority of contaminating peptide is racemized leupeptin. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Autosomal dominant Zellweger Spectrum Disorder caused by de novo variants in PEX14 gene: H.R. Waterham, et al.; Genet. Med. (2023),
Abstract;
GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin: S.O. Mattila, et al.; FASEB J.
35, e21654 (2021),
Abstract;
A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis: S.L. Dong, et al.; Emerg. Microbes Infect.
6, e105 (2017),
Abstract;
Full Text
Inhibition of Cyclic Adenosine Monophosphate-Specific Phosphodiesterase by Various Food Plant-Derived Phytotherapeutic Agents: T. Röhrig, et al.; Medicines (Basel)
4, 80 (2017),
Abstract;
Full Text
Autophagy of metallothioneins prevents TNF-induced oxidative stress and toxicity in hepatoma cells: C. Ullio et al.; Autophagy
11, 2184 (2015),
Abstract;
Full Text
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest.
125, 4612 (2015),
Application(s): Skeletal muscle cell culture,
Abstract;
Full Text
Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape: J. Dinter, et al.; PLoS Pathog.
11, e1004725 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin: M.A. Belaud-Rotureau, et al.; Cell Death Differ.
6, 788 (1999),
Abstract;
A protease-dependent TCR-induced death pathway in mature lymphocytes: A. Sarin, et al.; J. Immunol.
154, 5806 (1995),
Abstract;
Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors: A. Sarin, et al.; J. Immunol.
153, 862 (1994),
Abstract;
Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts: J.P. Montenez, et al.; Toxicol. Lett.
73, 201 (1994),
Abstract;
Isolation and characterization of leupeptins produced by Actinomycetes: S. Kondo, et al.; Chem. Pharm. Bull.
17, 1896 (1969),
Abstract;
