Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer's disease and by amyloid-β protein. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin. Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro.
Product Details
| Sequence: | H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH |
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| Formula: | C119H204N34O32S2 |
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| MW: | 2687.3 |
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| CAS: | 330936-69-1 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO or 5% acetic acid. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Humanin peptide suppresses apoptosis by interfering with Bax activation: B. Guo, et al.; Nature
423, 456 (2003),
Abstract;
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta: Y. Hashimoto, et al.; PNAS
98, 6336 (2001),
Abstract;
Full Text
Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults: Y. Hashimoto, et al.; J. Neurosci.
21, 9235 (2001),
Abstract;
Full Text
Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein: Y. Hashimoto, et al.; BBRC
283, 460 (2001),
Abstract;
