Product Details
Alternative Name: | HSTF2, Heat shock factor protein 2 |
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Clone: | 3E2 |
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Host: | Rat |
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Isotype: | IgG |
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Immunogen: | Recombinant mouse HSF2. |
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UniProt ID: | P38533 |
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Source: | Purified from mouse ascites. |
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Species reactivity: | Human, Mouse, Rat Bovine, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep
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Applications: | WB
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Recommended Dilutions/Conditions: | Western Blot (4µg/ml, colorimetric) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Western Blot (4µg/ml, colorimetric) Optimal conditions must be determined individually for each application. |
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Purity Detail: | Protein G affinity purified. |
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Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | HSFs (Heat Shock family of transcription factors), which consists of HSF 1-4, bind to highly conserved Heat shock elements (HSEs) in the promoter regions of heat shock genes, ultimately regulating the expression of Heat shock proteins (Hsps). On exposure to heat shock and other stresses, HSF1 localizes within seconds to discrete nuclear granules and on recovery from stress, HSF1 rapidly dissipates from the stress granules to a diffuse nucleoplasmic distribution. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition: G. Figlia, et al.; Nat. Cell Biol.
24, 1407 (2022),
Abstract;