Product Details
| Alternative Name: | Superoxide Dismutase, SOD3 |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to a portion of EC SOD. The sequence is completely conserved in human, mouse, rat and rabbit. |
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| UniProt ID: | P08294 |
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| Source: | Purified from rabbit serum. |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~35-40kDa (glycosylation dependent) by Western blot. |
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | SOD (Superoxide dismutase) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells, they are: EC SOD (extracellular SOD), Cu/Zn SOD (copper and zinc-containing SOD) and Mn SOD (manganese-containing SOD). |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of EC SOD: Lane 1: MW Marker, Lane 2: Rat Lung Tissue Extract, Lane 3: Mouse Lung Tissue Extract, Lane 4: Human EC SOD Protein.
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Product Literature References
Potential Role of Superoxide Dismutase 3 (SOD3) in Resistance to Influenza A Virus Infection: F. Chen, et al.; Antioxidants
12, 354 (2023),
Abstract;
Cerebrovascular endothelial dysfunction induced by mercury exposure at low concentrations: G.A. Wiggers, et al.; Neurotoxicology
53, 282 (2016),
Application(s): Western blot,
Abstract;
Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease: R.J. Tan, et al.; J. Am. Soc. Nephrol.
26, 2447 (2015),
Application(s): IHC on FFPE human kidney sections,
Abstract;
Full Text
MAPK pathway activation by chronic lead-exposure increases vascular reactivity through oxidative stress/cyclooxygenase-2-dependent pathways: M.R. Simões, et al.; Toxicol. Appl. Pharmacol.
283, 127 (2015),
Application(s): Western Blotting,
Abstract;
Hydrocortisone normalizes phosphodiesterase-5 activity in pulmonary artery smooth muscle cells from lambs with persistent pulmonary hypertension of the newborn: M. Perez, et al.; Pulm. Circ.
4, 71 (2014),
Application(s): WB using fetal lamb pulmonary arterial smooth muscle cell (FPASMC) lysates,
Abstract;
Full Text
Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein: L.V. d'Uscio, et al.; Cardiovasc. Res.
96, 504 (2012),
Application(s): Western Blot of mouse aorta lysates,
Abstract;
Full Text
Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries: M. Salaices, et al. ; Am. J. Physiol. Heart Circ. Physiol.
295, H1033 (2008),
Application(s): WB using rat tissue,
Abstract;
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